#------------------------------------------------------------------------------ #$Date: 2025-08-19 15:49:58 +0100 (Tue, 19 Aug 2025) $ #$Revision: 301806 $ #$URL: svn://www.crystallography.net/cod/cif/2/23/88/2238869.cif $ #------------------------------------------------------------------------------ # # This file is available in the Crystallography Open Database (COD), # http://www.crystallography.net/. The original data for this entry # were provided by IUCr Journals, http://journals.iucr.org/. # # The file may be used within the scientific community so long as # proper attribution is given to the journal article from which the # data were obtained. # data_2238869 loop_ _publ_author_name 'El-Emam, Ali A.' 'Al-Abdullah, Ebtehal S.' 'Al-Tuwaijri, Hanaa M.' 'Chidan Kumar, C. S.' 'Fun, Hoong-Kun' _publ_section_title ; N-(Adamantan-1-yl)-1,2,3,4-tetrahydroisoquinoline-2-carbothioamide ; _journal_coeditor_code HB7163 _journal_issue 12 _journal_name_full 'Acta Crystallographica Section E' _journal_page_first o1815 _journal_paper_doi 10.1107/S1600536813031516 _journal_volume 69 _journal_year 2013 _chemical_formula_iupac 'C20 H26 N2 S' _chemical_formula_moiety 'C20 H26 N2 S' _chemical_formula_sum 'C20 H26 N2 S' _chemical_formula_weight 326.49 _chemical_name_systematic ; N-(Adamantan-1-yl)-1,2,3,4-tetrahydroisoquinoline-2-carbothioamide ; _space_group_IT_number 14 _symmetry_cell_setting monoclinic _symmetry_space_group_name_Hall '-P 2ybc' _symmetry_space_group_name_H-M 'P 1 21/c 1' _atom_sites_solution_hydrogens geom _atom_sites_solution_primary direct _atom_sites_solution_secondary difmap _audit_creation_method SHELXL-97 _cell_angle_alpha 90.00 _cell_angle_beta 103.366(2) _cell_angle_gamma 90.00 _cell_formula_units_Z 4 _cell_length_a 19.1707(5) _cell_length_b 6.4106(2) _cell_length_c 14.2838(3) _cell_measurement_reflns_used 2009 _cell_measurement_temperature 296(2) _cell_measurement_theta_max 68.51 _cell_measurement_theta_min 4.74 _cell_volume 1707.87(8) _computing_cell_refinement 'SAINT (Bruker, 2009)' _computing_data_collection 'APEX2 (Bruker, 2009)' _computing_data_reduction 'SAINT (Bruker, 2009)' _computing_molecular_graphics 'SHELXTL (Sheldrick, 2008)' _computing_publication_material ; SHELXTL (Sheldrick, 2008) and PLATON (Spek, 2009) ; _computing_structure_refinement 'SHELXTL (Sheldrick, 2008)' _computing_structure_solution 'SHELXTL (Sheldrick, 2008)' _diffrn_ambient_temperature 296(2) _diffrn_measured_fraction_theta_full 0.970 _diffrn_measured_fraction_theta_max 0.970 _diffrn_measurement_device_type 'Bruker APEXII CCD' _diffrn_measurement_method '\f and \w scans' _diffrn_radiation_monochromator graphite _diffrn_radiation_source 'fine-focus sealed tube' _diffrn_radiation_type CuK\a _diffrn_radiation_wavelength 1.54178 _diffrn_reflns_av_R_equivalents 0.0396 _diffrn_reflns_av_sigmaI/netI 0.0475 _diffrn_reflns_limit_h_max 22 _diffrn_reflns_limit_h_min -22 _diffrn_reflns_limit_k_max 7 _diffrn_reflns_limit_k_min -5 _diffrn_reflns_limit_l_max 16 _diffrn_reflns_limit_l_min -16 _diffrn_reflns_number 10894 _diffrn_reflns_theta_full 65.00 _diffrn_reflns_theta_max 65.00 _diffrn_reflns_theta_min 4.74 _diffrn_standards_number 0 _exptl_absorpt_coefficient_mu 1.670 _exptl_absorpt_correction_T_max 0.9211 _exptl_absorpt_correction_T_min 0.3448 _exptl_absorpt_correction_type multi-scan _exptl_absorpt_process_details '(SADABS; Bruker, 2009)' _exptl_crystal_colour colorless _exptl_crystal_density_diffrn 1.270 _exptl_crystal_density_method 'not measured' _exptl_crystal_description needle _exptl_crystal_F_000 704 _exptl_crystal_size_max 0.81 _exptl_crystal_size_mid 0.13 _exptl_crystal_size_min 0.05 _refine_diff_density_max 0.164 _refine_diff_density_min -0.199 _refine_ls_extinction_method none _refine_ls_goodness_of_fit_ref 1.074 _refine_ls_hydrogen_treatment mixed _refine_ls_matrix_type full _refine_ls_number_parameters 212 _refine_ls_number_reflns 2831 _refine_ls_number_restraints 0 _refine_ls_restrained_S_all 1.074 _refine_ls_R_factor_all 0.0512 _refine_ls_R_factor_gt 0.0412 _refine_ls_shift/su_max 0.001 _refine_ls_shift/su_mean 0.000 _refine_ls_structure_factor_coef Fsqd _refine_ls_weighting_details 'calc w=1/[\s^2^(Fo^2^)+(0.0467P)^2^+0.4078P] where P=(Fo^2^+2Fc^2^)/3' _refine_ls_weighting_scheme calc _refine_ls_wR_factor_gt 0.1075 _refine_ls_wR_factor_ref 0.1143 _reflns_number_gt 2351 _reflns_number_total 2831 _reflns_threshold_expression I>2\s(I) _iucr_refine_instructions_details ; TITL HT14 in P2(1)/c CELL 1.54178 19.1707 6.4106 14.2838 90.000 103.366 90.000 ZERR 4.00 0.0005 0.0002 0.0003 0.000 0.002 0.000 LATT 1 SYMM -X, 0.5+Y, 0.5-Z SFAC C H N S UNIT 80 104 8 4 TEMP 23.000 L.S. 10 BOND $H ACTA CONF size 0.05 0.128 0.81 FMAP 2 omit -4 130 WGHT 0.0467 0.4078 PLAN 20 FVAR 0.14491 S1 4 0.285376 0.537086 0.878521 11.00000 0.05196 0.03272 = 0.05526 -0.00361 0.00262 0.00237 N1 3 0.316936 0.839217 1.010502 11.00000 0.03943 0.03483 = 0.04769 -0.00227 0.00541 0.00077 N2 3 0.225853 0.914518 0.881920 11.00000 0.04638 0.03646 = 0.05766 -0.01104 -0.00243 0.00638 C1 1 0.306517 1.046261 1.049855 11.00000 0.04453 0.04220 = 0.05091 -0.00487 0.01151 0.00466 AFIX 23 H1A 2 0.258155 1.055529 1.059477 11.00000 -1.20000 H1B 2 0.311764 1.152426 1.003582 11.00000 -1.20000 AFIX 0 C2 1 0.359561 1.088931 1.144646 11.00000 0.05144 0.04591 = 0.04483 -0.00624 0.01266 0.00206 AFIX 23 H2A 2 0.357453 1.235243 1.161085 11.00000 -1.20000 H2B 2 0.346639 1.007194 1.195237 11.00000 -1.20000 AFIX 0 C3 1 0.434446 1.034614 1.138171 11.00000 0.04668 0.04395 = 0.02879 0.00206 0.00799 -0.00159 C4 1 0.493190 1.164124 1.168059 11.00000 0.05918 0.04691 = 0.03607 -0.00049 0.00658 -0.00840 AFIX 43 H4A 2 0.487413 1.296068 1.192259 11.00000 -1.20000 AFIX 0 C5 1 0.560690 1.096395 1.161783 11.00000 0.04723 0.07078 = 0.04404 0.00064 0.00742 -0.01739 AFIX 43 H5A 2 0.600284 1.182763 1.182039 11.00000 -1.20000 AFIX 0 C6 1 0.569045 0.901740 1.125645 11.00000 0.04224 0.08286 = 0.04159 0.00295 0.01199 0.00179 AFIX 43 H6A 2 0.614558 0.855624 1.123068 11.00000 -1.20000 AFIX 0 C7 1 0.510266 0.773513 1.093003 11.00000 0.05342 0.05638 = 0.03653 -0.00176 0.00871 0.01037 AFIX 43 H7A 2 0.516161 0.643078 1.067390 11.00000 -1.20000 AFIX 0 C8 1 0.442631 0.840605 1.098710 11.00000 0.04342 0.04167 = 0.03108 0.00181 0.00497 0.00158 C9 1 0.376385 0.710728 1.065449 11.00000 0.04998 0.03682 = 0.04902 0.00209 0.00166 0.00271 AFIX 23 H9A 2 0.386292 0.597782 1.025224 11.00000 -1.20000 H9B 2 0.362607 0.650087 1.120733 11.00000 -1.20000 AFIX 0 C10 1 0.275875 0.774942 0.925318 11.00000 0.03443 0.03569 = 0.04729 0.00150 0.01010 -0.00292 C11 1 0.179226 0.918169 0.783501 11.00000 0.03403 0.03087 = 0.05040 -0.00038 0.00467 -0.00023 C12 1 0.135429 1.119395 0.779372 11.00000 0.05012 0.03954 = 0.07130 -0.00891 -0.00160 0.00685 AFIX 23 H12A 2 0.167575 1.237908 0.793889 11.00000 -1.20000 H12B 2 0.106908 1.113952 0.827257 11.00000 -1.20000 AFIX 0 C13 1 0.086045 1.146479 0.679132 11.00000 0.05260 0.03624 = 0.06944 0.00182 -0.00021 0.01238 AFIX 13 H13A 2 0.058907 1.276559 0.677288 11.00000 -1.20000 AFIX 0 C14 1 0.034426 0.964653 0.658667 11.00000 0.04199 0.06038 = 0.05952 0.00456 0.00025 0.00243 AFIX 23 H14A 2 0.002835 0.980198 0.595374 11.00000 -1.20000 H14B 2 0.005280 0.960997 0.705843 11.00000 -1.20000 AFIX 0 C15 1 0.076966 0.763946 0.663174 11.00000 0.05894 0.03685 = 0.06589 0.00188 -0.01267 -0.00771 AFIX 13 H15A 2 0.043711 0.645797 0.649707 11.00000 -1.20000 AFIX 0 C16 1 0.126367 0.736498 0.763237 11.00000 0.04613 0.03891 = 0.05870 0.01031 0.00197 -0.00584 AFIX 23 H16A 2 0.098114 0.732766 0.811460 11.00000 -1.20000 H16B 2 0.152306 0.605855 0.766124 11.00000 -1.20000 AFIX 0 C17 1 0.121407 0.769920 0.588516 11.00000 0.10106 0.06637 = 0.05017 -0.00857 -0.00299 0.03662 AFIX 23 H17A 2 0.090173 0.783028 0.524847 11.00000 -1.20000 H17B 2 0.148275 0.641089 0.590719 11.00000 -1.20000 AFIX 0 C18 1 0.172878 0.954025 0.607923 11.00000 0.06904 0.09753 = 0.05968 0.02481 0.02978 0.02510 AFIX 13 H18A 2 0.201273 0.958681 0.559042 11.00000 -1.20000 AFIX 0 C19 1 0.222929 0.927651 0.708230 11.00000 0.04330 0.06704 = 0.07492 0.01771 0.02137 0.00810 AFIX 23 H19A 2 0.250621 0.800458 0.710072 11.00000 -1.20000 H19B 2 0.256055 1.044101 0.721555 11.00000 -1.20000 AFIX 0 C20 1 0.130337 1.155583 0.605087 11.00000 0.06714 0.06433 = 0.08443 0.03542 0.00919 0.00140 AFIX 23 H20A 2 0.162911 1.273353 0.618156 11.00000 -1.20000 H20B 2 0.099292 1.174187 0.541616 11.00000 -1.20000 AFIX 0 H1N2 2 0.227720 1.034257 0.908459 11.00000 0.05117 HKLF 4 1 0 0 1 0 -1 0 1 0 0 REM b in P2(1)/c REM R1 = 0.0432 for 2493 Fo > 4sig(Fo) and 0.0551 for all 3090 data REM 212 parameters refined using 0 restraints END REM Highest difference peak 0.200, deepest hole -0.192, 1-sigma level 0.042 Q1 1 0.3235 0.6056 0.8255 11.00000 0.05 0.20 Q2 1 0.0571 0.8644 0.6633 11.00000 0.05 0.17 Q3 1 0.3284 0.4780 0.8218 11.00000 0.05 0.16 Q4 1 0.2948 0.7121 0.8820 11.00000 0.05 0.15 Q5 1 0.5618 1.0287 1.1185 11.00000 0.05 0.15 Q6 1 0.2498 0.4863 0.9204 11.00000 0.05 0.15 Q7 1 0.1772 0.7263 0.5761 11.00000 0.05 0.15 Q8 1 0.1442 1.0617 0.5775 11.00000 0.05 0.15 Q9 1 0.3786 0.5703 1.0719 11.00000 0.05 0.14 Q10 1 0.2007 0.9568 0.6571 11.00000 0.05 0.14 Q11 1 0.2476 0.5844 0.9175 11.00000 0.05 0.14 Q12 1 0.3477 0.5146 0.9005 11.00000 0.05 0.14 Q13 1 0.1798 0.8906 0.5538 11.00000 0.05 0.13 Q14 1 0.1563 0.8335 0.7822 11.00000 0.05 0.13 Q15 1 0.4623 0.8420 1.0585 11.00000 0.05 0.13 Q16 1 0.4526 1.1062 1.1210 11.00000 0.05 0.13 Q17 1 0.4342 0.9792 1.0873 11.00000 0.05 0.13 Q18 1 0.5381 0.8114 1.1262 11.00000 0.05 0.13 Q19 1 0.2652 0.4920 0.9441 11.00000 0.05 0.13 Q20 1 0.2767 0.5499 0.7962 11.00000 0.05 0.13 ; _cod_data_source_file hb7163.cif _cod_data_source_block I _cod_original_sg_symbol_H-M 'P 21/c' _cod_database_code 2238869 loop_ _symmetry_equiv_pos_as_xyz 'x, y, z' '-x, y+1/2, -z+1/2' '-x, -y, -z' 'x, -y-1/2, z-1/2' loop_ _atom_site_type_symbol _atom_site_label _atom_site_fract_x _atom_site_fract_y _atom_site_fract_z _atom_site_U_iso_or_equiv _atom_site_adp_type _atom_site_calc_flag _atom_site_refinement_flags _atom_site_occupancy _atom_site_symmetry_multiplicity S S1 0.28539(3) 0.53707(8) 0.87853(4) 0.04780(18) Uani d . 1 1 N N1 0.31695(8) 0.8392(2) 1.01049(11) 0.0410(4) Uani d . 1 1 N N2 0.22585(9) 0.9145(3) 0.88193(13) 0.0487(4) Uani d . 1 1 C C1 0.30653(10) 1.0463(3) 1.04991(15) 0.0454(5) Uani d . 1 1 H H1A 0.2582 1.0555 1.0596 0.054 Uiso calc R 1 1 H H1B 0.3118 1.1525 1.0037 0.054 Uiso calc R 1 1 C C2 0.35954(10) 1.0889(3) 1.14462(14) 0.0468(5) Uani d . 1 1 H H2A 0.3574 1.2352 1.1611 0.056 Uiso calc R 1 1 H H2B 0.3466 1.0071 1.1952 0.056 Uiso calc R 1 1 C C3 0.43444(10) 1.0346(3) 1.13817(13) 0.0394(4) Uani d . 1 1 C C4 0.49318(11) 1.1642(3) 1.16802(14) 0.0477(5) Uani d . 1 1 H H4A 0.4874 1.2961 1.1922 0.057 Uiso calc R 1 1 C C5 0.56065(11) 1.0963(4) 1.16170(15) 0.0541(6) Uani d . 1 1 H H5A 0.6002 1.1827 1.1819 0.065 Uiso calc R 1 1 C C6 0.56903(11) 0.9017(4) 1.12565(15) 0.0549(6) Uani d . 1 1 H H6A 0.6146 0.8556 1.1231 0.066 Uiso calc R 1 1 C C7 0.51028(10) 0.7734(3) 1.09301(13) 0.0485(5) Uani d . 1 1 H H7A 0.5162 0.6430 1.0674 0.058 Uiso calc R 1 1 C C8 0.44261(10) 0.8406(3) 1.09868(13) 0.0388(4) Uani d . 1 1 C C9 0.37639(10) 0.7106(3) 1.06543(14) 0.0464(5) Uani d . 1 1 H H9A 0.3863 0.5977 1.0252 0.056 Uiso calc R 1 1 H H9B 0.3626 0.6500 1.1207 0.056 Uiso calc R 1 1 C C10 0.27588(9) 0.7748(3) 0.92530(14) 0.0386(4) Uani d . 1 1 C C11 0.17921(9) 0.9182(3) 0.78351(14) 0.0388(4) Uani d . 1 1 C C12 0.13539(11) 1.1194(3) 0.77934(17) 0.0559(6) Uani d . 1 1 H H12A 0.1675 1.2379 0.7938 0.067 Uiso calc R 1 1 H H12B 0.1069 1.1140 0.8272 0.067 Uiso calc R 1 1 C C13 0.08603(11) 1.1464(3) 0.67914(16) 0.0545(6) Uani d . 1 1 H H13A 0.0589 1.2764 0.6773 0.065 Uiso calc R 1 1 C C14 0.03443(11) 0.9647(4) 0.65865(17) 0.0556(6) Uani d . 1 1 H H14A 0.0029 0.9802 0.5953 0.067 Uiso calc R 1 1 H H14B 0.0053 0.9610 0.7058 0.067 Uiso calc R 1 1 C C15 0.07696(12) 0.7641(3) 0.66319(17) 0.0580(6) Uani d . 1 1 H H15A 0.0437 0.6459 0.6497 0.070 Uiso calc R 1 1 C C16 0.12637(10) 0.7366(3) 0.76323(15) 0.0491(5) Uani d . 1 1 H H16A 0.0981 0.7328 0.8115 0.059 Uiso calc R 1 1 H H16B 0.1523 0.6060 0.7661 0.059 Uiso calc R 1 1 C C17 0.12141(15) 0.7699(4) 0.58855(17) 0.0754(8) Uani d . 1 1 H H17A 0.0902 0.7830 0.5249 0.090 Uiso calc R 1 1 H H17B 0.1483 0.6411 0.5908 0.090 Uiso calc R 1 1 C C18 0.17292(14) 0.9540(5) 0.60795(19) 0.0727(8) Uani d . 1 1 H H18A 0.2013 0.9586 0.5591 0.087 Uiso calc R 1 1 C C19 0.22293(11) 0.9277(4) 0.70823(17) 0.0599(6) Uani d . 1 1 H H19A 0.2506 0.8006 0.7101 0.072 Uiso calc R 1 1 H H19B 0.2560 1.0442 0.7215 0.072 Uiso calc R 1 1 C C20 0.13032(13) 1.1555(4) 0.6051(2) 0.0729(7) Uani d . 1 1 H H20A 0.1629 1.2734 0.6181 0.087 Uiso calc R 1 1 H H20B 0.0993 1.1740 0.5416 0.087 Uiso calc R 1 1 H H1N2 0.2278(11) 1.034(4) 0.9084(15) 0.051(6) Uiso d . 1 1 loop_ _atom_site_aniso_label _atom_site_aniso_U_11 _atom_site_aniso_U_22 _atom_site_aniso_U_33 _atom_site_aniso_U_12 _atom_site_aniso_U_13 _atom_site_aniso_U_23 S1 0.0513(3) 0.0321(3) 0.0554(4) 0.0024(2) 0.0028(2) -0.0036(2) N1 0.0388(8) 0.0340(9) 0.0481(10) 0.0010(6) 0.0057(7) -0.0023(7) N2 0.0455(9) 0.0361(11) 0.0575(11) 0.0066(7) -0.0024(8) -0.0109(8) C1 0.0437(11) 0.0419(12) 0.0509(12) 0.0046(8) 0.0117(9) -0.0049(8) C2 0.0508(12) 0.0453(12) 0.0451(12) 0.0021(9) 0.0126(9) -0.0060(9) C3 0.0456(11) 0.0434(12) 0.0290(10) -0.0016(8) 0.0082(8) 0.0022(7) C4 0.0589(12) 0.0463(12) 0.0359(11) -0.0082(9) 0.0067(9) -0.0005(8) C5 0.0464(12) 0.0705(16) 0.0440(12) -0.0172(11) 0.0076(10) 0.0007(10) C6 0.0420(11) 0.0819(17) 0.0419(12) 0.0021(11) 0.0121(9) 0.0031(11) C7 0.0528(12) 0.0557(13) 0.0363(11) 0.0108(10) 0.0088(9) -0.0016(9) C8 0.0430(10) 0.0406(11) 0.0309(10) 0.0017(8) 0.0049(8) 0.0020(7) C9 0.0493(11) 0.0363(11) 0.0490(12) 0.0027(9) 0.0020(9) 0.0021(8) C10 0.0336(9) 0.0353(10) 0.0472(12) -0.0029(7) 0.0101(8) 0.0012(8) C11 0.0333(9) 0.0306(10) 0.0501(12) 0.0003(7) 0.0046(8) -0.0002(8) C12 0.0495(12) 0.0392(13) 0.0717(15) 0.0064(9) -0.0010(11) -0.0092(10) C13 0.0521(12) 0.0348(12) 0.0698(15) 0.0127(9) 0.0002(11) 0.0022(9) C14 0.0413(11) 0.0607(15) 0.0593(14) 0.0029(9) 0.0004(10) 0.0047(10) C15 0.0582(13) 0.0365(13) 0.0661(15) -0.0082(10) -0.0124(11) 0.0015(10) C16 0.0454(11) 0.0386(12) 0.0587(13) -0.0052(9) 0.0024(9) 0.0102(9) C17 0.1000(19) 0.0659(18) 0.0500(15) 0.0366(15) -0.0034(14) -0.0084(11) C18 0.0681(16) 0.098(2) 0.0596(16) 0.0250(14) 0.0300(13) 0.0246(14) C19 0.0428(11) 0.0660(16) 0.0751(16) 0.0084(10) 0.0219(11) 0.0182(12) C20 0.0663(15) 0.0633(17) 0.0850(18) 0.0017(12) 0.0093(14) 0.0356(13) loop_ _atom_type_symbol _atom_type_description _atom_type_scat_dispersion_real _atom_type_scat_dispersion_imag _atom_type_scat_source C C 0.0181 0.0091 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' H H 0.0000 0.0000 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' N N 0.0311 0.0180 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' S S 0.3331 0.5567 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' loop_ _geom_angle_atom_site_label_1 _geom_angle_atom_site_label_2 _geom_angle_atom_site_label_3 _geom_angle C10 N1 C1 121.12(15) C10 N1 C9 121.67(16) C1 N1 C9 117.13(15) C10 N2 C11 130.81(17) C10 N2 H1N2 116.1(15) C11 N2 H1N2 111.1(15) N1 C1 C2 112.39(16) N1 C1 H1A 109.1 C2 C1 H1A 109.1 N1 C1 H1B 109.1 C2 C1 H1B 109.1 H1A C1 H1B 107.9 C3 C2 C1 110.89(16) C3 C2 H2A 109.5 C1 C2 H2A 109.5 C3 C2 H2B 109.5 C1 C2 H2B 109.5 H2A C2 H2B 108.0 C4 C3 C8 120.13(18) C4 C3 C2 124.29(18) C8 C3 C2 115.58(17) C3 C4 C5 119.7(2) C3 C4 H4A 120.1 C5 C4 H4A 120.1 C6 C5 C4 120.06(19) C6 C5 H5A 120.0 C4 C5 H5A 120.0 C5 C6 C7 120.60(19) C5 C6 H6A 119.7 C7 C6 H6A 119.7 C6 C7 C8 119.6(2) C6 C7 H7A 120.2 C8 C7 H7A 120.2 C7 C8 C3 119.76(18) C7 C8 C9 122.91(18) C3 C8 C9 117.32(16) N1 C9 C8 110.52(16) N1 C9 H9A 109.5 C8 C9 H9A 109.5 N1 C9 H9B 109.5 C8 C9 H9B 109.5 H9A C9 H9B 108.1 N1 C10 N2 114.44(17) N1 C10 S1 122.50(14) N2 C10 S1 123.05(15) N2 C11 C19 111.34(16) N2 C11 C16 113.34(16) C19 C11 C16 110.43(18) N2 C11 C12 104.80(16) C19 C11 C12 109.13(17) C16 C11 C12 107.50(16) C11 C12 C13 110.23(17) C11 C12 H12A 109.6 C13 C12 H12A 109.6 C11 C12 H12B 109.6 C13 C12 H12B 109.6 H12A C12 H12B 108.1 C20 C13 C14 110.2(2) C20 C13 C12 109.55(18) C14 C13 C12 109.20(18) C20 C13 H13A 109.3 C14 C13 H13A 109.3 C12 C13 H13A 109.3 C13 C14 C15 108.90(17) C13 C14 H14A 109.9 C15 C14 H14A 109.9 C13 C14 H14B 109.9 C15 C14 H14B 109.9 H14A C14 H14B 108.3 C17 C15 C14 109.51(19) C17 C15 C16 109.45(18) C14 C15 C16 110.37(19) C17 C15 H15A 109.2 C14 C15 H15A 109.2 C16 C15 H15A 109.2 C11 C16 C15 109.25(16) C11 C16 H16A 109.8 C15 C16 H16A 109.8 C11 C16 H16B 109.8 C15 C16 H16B 109.8 H16A C16 H16B 108.3 C15 C17 C18 109.80(19) C15 C17 H17A 109.7 C18 C17 H17A 109.7 C15 C17 H17B 109.7 C18 C17 H17B 109.7 H17A C17 H17B 108.2 C17 C18 C20 109.3(2) C17 C18 C19 108.9(2) C20 C18 C19 109.4(2) C17 C18 H18A 109.7 C20 C18 H18A 109.7 C19 C18 H18A 109.7 C11 C19 C18 109.80(17) C11 C19 H19A 109.7 C18 C19 H19A 109.7 C11 C19 H19B 109.7 C18 C19 H19B 109.7 H19A C19 H19B 108.2 C13 C20 C18 109.52(18) C13 C20 H20A 109.8 C18 C20 H20A 109.8 C13 C20 H20B 109.8 C18 C20 H20B 109.8 H20A C20 H20B 108.2 loop_ _geom_bond_atom_site_label_1 _geom_bond_atom_site_label_2 _geom_bond_distance S1 C10 1.6906(19) N1 C10 1.352(2) N1 C1 1.473(2) N1 C9 1.477(2) N2 C10 1.353(2) N2 C11 1.482(2) N2 H1N2 0.85(2) C1 C2 1.517(3) C1 H1A 0.9700 C1 H1B 0.9700 C2 C3 1.501(3) C2 H2A 0.9700 C2 H2B 0.9700 C3 C4 1.385(3) C3 C8 1.389(3) C4 C5 1.387(3) C4 H4A 0.9300 C5 C6 1.373(3) C5 H5A 0.9300 C6 C7 1.385(3) C6 H6A 0.9300 C7 C8 1.387(3) C7 H7A 0.9300 C8 C9 1.501(3) C9 H9A 0.9700 C9 H9B 0.9700 C11 C19 1.510(3) C11 C16 1.526(2) C11 C12 1.533(3) C12 C13 1.532(3) C12 H12A 0.9700 C12 H12B 0.9700 C13 C20 1.503(3) C13 C14 1.512(3) C13 H13A 0.9800 C14 C15 1.516(3) C14 H14A 0.9700 C14 H14B 0.9700 C15 C17 1.511(4) C15 C16 1.531(3) C15 H15A 0.9800 C16 H16A 0.9700 C16 H16B 0.9700 C17 C18 1.522(4) C17 H17A 0.9700 C17 H17B 0.9700 C18 C20 1.524(4) C18 C19 1.538(3) C18 H18A 0.9800 C19 H19A 0.9700 C19 H19B 0.9700 C20 H20A 0.9700 C20 H20B 0.9700 loop_ _geom_hbond_atom_site_label_D _geom_hbond_atom_site_label_H _geom_hbond_atom_site_label_A _geom_hbond_distance_DH _geom_hbond_distance_HA _geom_hbond_distance_DA _geom_hbond_angle_DHA _geom_hbond_publ_flag C16 H16B S1 0.97 2.72 3.365(2) 125 yes loop_ _geom_torsion_atom_site_label_1 _geom_torsion_atom_site_label_2 _geom_torsion_atom_site_label_3 _geom_torsion_atom_site_label_4 _geom_torsion C10 N1 C1 C2 -178.44(16) C9 N1 C1 C2 -1.5(2) N1 C1 C2 C3 47.4(2) C1 C2 C3 C4 131.5(2) C1 C2 C3 C8 -48.2(2) C8 C3 C4 C5 -2.4(3) C2 C3 C4 C5 177.96(19) C3 C4 C5 C6 0.2(3) C4 C5 C6 C7 1.7(3) C5 C6 C7 C8 -1.4(3) C6 C7 C8 C3 -0.8(3) C6 C7 C8 C9 -179.65(18) C4 C3 C8 C7 2.7(3) C2 C3 C8 C7 -177.63(17) C4 C3 C8 C9 -178.40(17) C2 C3 C8 C9 1.2(3) C10 N1 C9 C8 133.07(17) C1 N1 C9 C8 -43.8(2) C7 C8 C9 N1 -136.37(18) C3 C8 C9 N1 44.8(2) C1 N1 C10 N2 -0.3(3) C9 N1 C10 N2 -177.09(16) C1 N1 C10 S1 -179.06(14) C9 N1 C10 S1 4.2(2) C11 N2 C10 N1 169.16(18) C11 N2 C10 S1 -12.1(3) C10 N2 C11 C19 -61.5(3) C10 N2 C11 C16 63.7(3) C10 N2 C11 C12 -179.4(2) N2 C11 C12 C13 178.19(16) C19 C11 C12 C13 58.8(2) C16 C11 C12 C13 -60.9(2) C11 C12 C13 C20 -59.5(2) C11 C12 C13 C14 61.2(2) C20 C13 C14 C15 60.7(2) C12 C13 C14 C15 -59.6(2) C13 C14 C15 C17 -60.3(2) C13 C14 C15 C16 60.2(2) N2 C11 C16 C15 175.54(16) C19 C11 C16 C15 -58.8(2) C12 C11 C16 C15 60.2(2) C17 C15 C16 C11 59.4(2) C14 C15 C16 C11 -61.2(2) C14 C15 C17 C18 60.0(2) C16 C15 C17 C18 -61.1(2) C15 C17 C18 C20 -58.9(3) C15 C17 C18 C19 60.6(2) N2 C11 C19 C18 -174.24(19) C16 C11 C19 C18 58.9(2) C12 C11 C19 C18 -59.0(2) C17 C18 C19 C11 -59.3(3) C20 C18 C19 C11 60.2(3) C14 C13 C20 C18 -60.1(3) C12 C13 C20 C18 60.0(3) C17 C18 C20 C13 58.8(3) C19 C18 C20 C13 -60.4(3) loop_ _cod_related_entry_id _cod_related_entry_database _cod_related_entry_code 1 PubChem 127090085